Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 84295
Gene Symbol: PHF6
PHF6 		0.700 Biomarker disease GENOMICS_ENGLAND Overall, these results identify PHF6 as a new X-linked tumor suppressor in T-ALL and point to a strong genetic interaction between PHF6 loss and aberrant expression of TLX transcription factors in the pathogenesis of this disease. 20228800 2010
Entrez Id: 4849
Gene Symbol: CNOT3
CNOT3 		0.640 SomaticCausalMutation disease ORPHANET We identify CNOT3 as a tumor suppressor mutated in 7 of 89 (7.9%) adult T-ALLs, and its knockdown causes tumors in a sensitized Drosophila melanogaster model. 23263491 2013
Entrez Id: 25
Gene Symbol: ABL1
ABL1 		0.600 FusionGene disease ORPHANET Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia. 29279377 2018
Entrez Id: 6886
Gene Symbol: TAL1
TAL1 		0.600 FusionGene disease ORPHANET
Entrez Id: 3195
Gene Symbol: TLX1
TLX1 		0.600 FusionGene disease ORPHANET TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression. 22516263 2012
Entrez Id: 3195
Gene Symbol: TLX1
TLX1 		0.600 FusionGene disease ORPHANET Hijacking T cell differentiation: new insights in TLX function in T-ALL. 22516255 2012
Entrez Id: 4602
Gene Symbol: MYB
MYB 		0.590 FusionGene disease ORPHANET
Entrez Id: 30012
Gene Symbol: TLX3
TLX3 		0.400 FusionGene disease ORPHANET Hijacking T cell differentiation: new insights in TLX function in T-ALL. 22516255 2012
Entrez Id: 4609
Gene Symbol: MYC
MYC 		0.400 FusionGene disease ORPHANET
Entrez Id: 6491
Gene Symbol: STIL
STIL 		0.400 FusionGene disease ORPHANET
Entrez Id: 30012
Gene Symbol: TLX3
TLX3 		0.400 FusionGene disease ORPHANET TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression. 22516263 2012
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		0.400 SomaticCausalMutation disease ORPHANET A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups. 18838613 2009
Entrez Id: 8021
Gene Symbol: NUP214
NUP214 		0.400 FusionGene disease ORPHANET Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia. 29279377 2018
Entrez Id: 613
Gene Symbol: BCR
BCR 		0.380 FusionGene disease ORPHANET
Entrez Id: 6418
Gene Symbol: SET
SET 		0.370 FusionGene disease ORPHANET Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia. 29279377 2018
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.370 SomaticCausalMutation disease ORPHANET Detection of FLT3 gene and FLT3/ITD mutation by polymerase chain reaction-single-strand conformation polymorphism in patients with acute lymphoblastic leukemia. 16234090 2005
Entrez Id: 8028
Gene Symbol: MLLT10
MLLT10 		0.370 FusionGene disease ORPHANET The present study showed MLLT10 promiscuity in pediatric T-ALL and identified a specific MLLT10 signature within the HOXA subgroup. 23673860 2013
Entrez Id: 6965
Gene Symbol: TRG
TRG 		0.370 GeneticVariation disease ORPHANET
Entrez Id: 6964
Gene Symbol: TRD
TRD 		0.360 FusionGene disease ORPHANET
Entrez Id: 8301
Gene Symbol: PICALM
PICALM 		0.350 FusionGene disease ORPHANET
Entrez Id: 6957
Gene Symbol: TRB
TRB 		0.330 FusionGene disease ORPHANET
Entrez Id: 6955
Gene Symbol: TRA
TRA 		0.320 FusionGene disease ORPHANET Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia. 29279377 2018
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A 		0.310 FusionGene disease ORPHANET
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16 		0.300 FusionGene disease ORPHANET Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia. 29279377 2018
Entrez Id: 3187
Gene Symbol: HNRNPH1
HNRNPH1 		0.300 FusionGene disease ORPHANET In pediatric T-ALL, we have identified 2 RNA processing genes, that is, HNRNPH1/5q35 and DDX3X/Xp11.3 as new MLLT10 fusion partners. 23673860 2013